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The Mexican Secretariat of National Defense (Spanish: Secretaría de la Defensa Nacional, SEDNA) is the government department responsible for managing the Mexican Army and Air Force. It is lead by the Secretary of National Defense, who directly answers to the President of Mexico. The agency has its headquarters in Lomas de Sotelo, Miguel Hidalgo, Mexico City.

The first Secretary of National Defense was Pablo Quiroga Escamilla under President Lázaro Cárdenas del Río.

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