User blog comment:TheDarknessRises/Riddle Me This, Peter Parker: Mysterio v. The Riddler/@comment-422690-20130302224519

So...

Hand-to-hand: Question Mark Cane wins. They exert the same amount of force, but the cane is longer. Ergo, it's a better weapon. Edge: Riddler.

Firearms: Tie. The Glock has more bullets by two. The S&W has more range by 5 yards. Not all that huge a difference. Edge: None.

Explosives: Pipe bomb wins. Packs more explosives and can be easily set up, as opposed to the fact that the time bomb requires you to read your enemy's movements near-exactly. Edge: Mysterio.

Special: Hallucinogen wins. It's not lethal, but it's completely incapacitating. Not only that, but it outdistances the knives. Hallucinogens are quite a potent chemical weapon. Edge: Mysterio.

Overall: What Mysterio lacks in the hand-to-hand department he more than makes up for with the rest of his arsenal, especially that hallucinogenic gas. The gas is what will truly win it for him.