User blog comment:So-Pro Warrior/Special Sneak Preview of Season 2: Battle of the Ultimate Galaxy Savers: Master Chief vs. Commander Shepard/@comment-4248317-20130614153212/@comment-4248317-20130616161755

http://www.youtube.com/watch?v=m1KOEl9YBV0 You're right, MC does have amazing dodging skills (and this is canon, BTW).

I'm not saying Chief can move at the speed of light; Shepard is still going to get a number of shots in. But do you expect me to believe that being able to run 55 MPH, as well as having a reaction time 300% superior to a normal human's isn't going to allow him to avoid anything?

Also, just because certain biotic abilities are "lock-on" does not mean they will automatically hit every time. If someone aims wrong, or if the target moves behind cover after the ability is used, a projectile such as Throw can miss or harmlessly hit a wall. I can tell you from personal experience that this is possible.