Chise

A clumsy teenage girl with poor grades in every course except history, and a fan of shoujo manga, Chise was an unlikely candidate for becoming an living weapon of mass destruction. But, after the Japanese Self-Defense Force found out she was compatible with cybernetic weapons, wings, and jetpacks, Chise became just that, being deployed against an unknown enemy at war with Japan, apparently over territory.

Saikano takes place in grim alternate reality where, by the early 21st century, much of the Earth had become uninhabitable by human actions. Japan, was one of the inhabitable places remaining, and a multinational invasion was sparked to take control of the inhabitable territory. Chise was deployed against these invasion forces, causing severe casualties, but also causing large amounts of collateral friendly fire damage.

The war serves as a backdrop for the story of Chise's relationship with her boyfriend, Shuji, who discovers that she is a military cyborg after he sees her sporting cybernetic wings and an arm-mounted Gatling gun, shortly after shooting down a squadron of enemy bombers. Saikano also explores the psychological destruction of Chise and those around her because of the horrors and tragedy that surround them. In the final episode of Saikano, an unspecified disaster strikes, apparently wiping out all life on Earth, save for Shuji, who Chise managed to save.

Chise's cybernetics include a 25mm GAU-12 Gatling Gun, missiles fired from her back, a powerful energy weapon capable of striking with the force of a small bomb, and most devastating of all, the ability to generate nuclear-level explosions seemingly at will. Chise is able to fly at least as fast as a fighter jet with her cybernetic wings and jets. Chise is extremely resiliant, even bordering on invincible, capable of surviving direct hits with shipborne anti-aircraft missiles with little damage, though at one point, her wings are damaged, and she does scream in pain in the final episode is she is struck with multiple missiles, suggest that if she sustains enough damage, she can be killed.