User blog comment:So-Pro Warrior/Special Sneak Preview of Season 2: Battle of the Ultimate Galaxy Savers: Master Chief vs. Commander Shepard/@comment-4248317-20130614153212

As a fan of both Halo and Mass Effect, I have to give this to Master Chief, though it will not be easy. What really clinches a win here, in my opinion, are Chief's vastly superior reflexes. While Shepard's biotics will no doubt be the biggest challenge, they have one major flaw: they are not instantaneous. Each one takes about second or so to use, and the Chief will see these coming a mile away, allowing him to find cover or interrupt the attack. Most of Shepard's biotic attacks, such as Shockwave, can be easily avoided, even by regular humans. Chief, with his 300% increased reflexes, should have little difficulty. Even if Chief gets hit with something like Lift, I highly doubt it is anywhere near as powerful as the Diadect's telekenisis. His reflexes will also allow him to avoid Shepard's weapons, or find cover and allow his shields to recharge if he does get hit.

Given Chief's ability to avoid Shepard's biotics/guns, as well as Shepard's kinetic barriers protecting him from the majority of Chief's weapons, neither warrior will be able to kill each other at a distance. As a result, the fight will inevitably move to close-quarters combat... and THIS is where the Chief will dominate with his vastly superior strength and hand-to-hand combat skills, as well as the fact that his armor covers his entire body, while Shepard's head is exposed. In addition, Chief's previously mentioned reflexes/reaction time should allow him to avoid a potential stab from the Omni-blade.

Deadliest Warrior: MASTER CHIEF